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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
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[Long term adherence to HAART in Senegal]
M Bastard1, M Basty Koita Fall,
1, Epicentre, 8, rue Saint-Sabin, 75011, Paris, France, mathieu.bastard@geneva.msf.org.
Bulletin De La Societe De Pathologie Exotique (1990)
|March 12, 2014
Summary
Antiretroviral treatment adherence in Senegal showed good long-term outcomes, with women exhibiting better adherence. However, male gender and low adherence increased mortality risk.
Area of Science:
- Public Health
- Infectious Diseases
- Pharmacology
Context:
- A 1998 governmental initiative in Senegal aimed to improve access to highly active antiretroviral therapy (HAART) for HIV patients.
- Long-term adherence data (November 1999 - June 2010) were collected from 330 patients.
Purpose:
- To explore predictors of adherence and identify adherence trajectories in HIV-infected patients.
- To analyze the relationship between adherence behaviors and mortality rates.
Summary:
- Three distinct adherence behaviors were identified, with women demonstrating superior adherence.
- Latent class mixed models revealed high adherence trajectories in one-third of patients and intermediate in another third.
- Survival analysis indicated that male gender and consistently low adherence were independent predictors of increased mortality.
Impact:
- The study demonstrates that sustained good adherence to antiretroviral therapy is achievable in Senegal.
- Findings highlight a subgroup of patients with intermediate adherence at risk for antiretroviral drug resistance.
- Results suggest targeted interventions may be necessary for specific patient groups, particularly men.
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