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Related Experiment Video

Updated: May 2, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Visual evoked potential and psychophysical contrast thresholds in glaucoma.

Siti Nurliyana Abdullah1, Gordon F Sanderson, Andrew C James

  • 1School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Documenta Ophthalmologica. Advances in Ophthalmology
|March 12, 2014
PubMed
Summary

Combining electrophysiological (VEP) and psychophysical (Psyc) contrast thresholds significantly improves glaucoma diagnosis. This combined approach offers a valuable, time-efficient tool for detecting glaucoma severity.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Glaucoma diagnosis relies on various methods, but improved accuracy and efficiency are continually sought.
  • Contrast sensitivity testing is crucial for early glaucoma detection.
  • Electrophysiological and psychophysical methods offer different insights into visual function.

Purpose of the Study:

  • To compare the diagnostic power of electrophysiologically measured visual evoked potential (VEP) and psychophysically measured contrast thresholds for glaucoma diagnosis.
  • To determine if combining VEP and psychophysical (Psyc) results enhances diagnostic accuracy.

Main Methods:

  • Seventy-eight subjects (21 normal controls, 57 glaucoma patients) aged 40-88 were tested.
  • Contrast thresholds were measured using a staircase method for VEP and Psyc with a 1 cpd grating.
  • Diagnostic power was assessed using receiver operating characteristic (ROC) plots and %AUC.

Main Results:

  • Psychophysical thresholds showed age dependence, while VEPs did not.
  • Individual diagnostic performance was modest (Psyc: 74%, VEP: 72%).
  • Combining VEP and Psyc thresholds significantly improved diagnostic power to 90% for moderate glaucoma, with benefits across all severities.

Conclusions:

  • Combining VEP and psychophysical contrast thresholds enhances glaucoma diagnostic power.
  • These methods measure independent aspects of glaucoma, correlating with disease severity.
  • Adding a brief psychophysical test to VEP testing provides significant diagnostic benefit with minimal time cost.