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Dual stimuli-responsive self-assembled supramolecular nanoparticles.

Carmen Stoffelen1, Jens Voskuhl, Pascal Jonkheijm

  • 1Molecular Nanofabrication group MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands) http://www.utwente.nl/tnw/mnf.

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Summary

Researchers developed dual responsive supramolecular nanoparticles (SNPs) using host-guest chemistry. These nanoparticles exhibit controlled assembly and disassembly, functioning as a supramolecular AND logic gate.

Keywords:
host-guest systemsnanoparticlesphotochemistryself-assemblysupramolecular chemistry

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Area of Science:

  • Supramolecular Chemistry
  • Nanotechnology
  • Materials Science

Background:

  • Supramolecular nanoparticles (SNPs) are assembled from multiple building blocks via noncovalent interactions.
  • Their multivalent nature allows for controlled size, assembly, and disassembly, showing promise for biomedical delivery.
  • Developing responsive and controllable SNP systems is crucial for advanced applications.

Purpose of the Study:

  • To create dual responsive supramolecular nanoparticles (SNPs) using a specific host-guest complexation system.
  • To investigate the assembly, disassembly, and photoresponsive behavior of these SNPs.
  • To demonstrate the potential of these SNPs as a supramolecular logic gate.

Main Methods:

  • Utilized ternary host-guest complexation involving cucurbit[8]uril (CB[8]), a methyl viologen (MV) polymer, and azobenzene (Azo) functionalized molecules.
  • Employed UV and Vis light to induce photoisomerization of the azobenzene groups.
  • Analyzed the disruption and disintegration kinetics of the supramolecular complexes and nanoparticles.

Main Results:

  • UV light rapidly disrupted the ternary complexes but caused slower disintegration of the SNPs.
  • Alternating UV and Vis light enabled fully reversible disassembly and reassembly of the SNPs.
  • SNPs formation was dependent on the trans state of Azo moieties and oxidized state of MV units, enabling an AND logic gate function.

Conclusions:

  • Dual responsive SNPs based on CB[8]/MV/Azo ternary complexes exhibit controlled photoresponsive behavior.
  • The reversible assembly/disassembly and logic gate function highlight the potential of these systems in advanced materials and drug delivery.
  • This work provides a foundation for designing sophisticated supramolecular systems with tunable properties.