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Omaezallene from red alga Laurencia sp.: structure elucidation, total synthesis, and antifouling activity
Taiki Umezawa1, Yuko Oguri, Hiroshi Matsuura
1Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810 (Japan).
Abstract:
Natural antifouling products have been the subject of considerable attention. We screened marine algae for antifouling activity and discovered omaezallenes, the new bromoallene-containing natural products isolated from the red alga Laurencia sp. Described is the isolation, structure elucidation, and total syntheses of omaezallenes. The relative and absolute configurations of natural omaezallenes were unambiguously established through total synthesis. The antifouling activities and ecotoxicity of omaezallenes were also evaluated.
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