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Implementing individualized medicine into the medical practice.

Konstantinos N Lazaridis, Tammy M McAllister, Dusica Babovic-Vuksanovic

    American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
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    Genomic medicine offers personalized patient care and tailored therapies. This review details an institution's approach to implementing whole exome sequencing in a clinical setting to advance individualized medicine.

    Keywords:
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    Area of Science:

    • Genomic Medicine
    • Individualized Medicine
    • Clinical Genomics

    Background:

    • Genomic medicine is increasingly recognized for its role in patient care, offering tailored therapies and improved outcomes.
    • Technological advancements and cost reductions are facilitating the integration of genomic medicine into clinical practice.
    • Significant challenges hinder the widespread adoption of genomics in mainstream medical practice.

    Purpose of the Study:

    • To describe an institution's strategy for implementing whole exome sequencing (WES) on a clinical basis.
    • To establish an enterprise-wide, standalone individualized medicine clinic for clinical genomics.
    • To share practical experiences and lessons learned from the design and execution of this clinic.

    Main Methods:

    • Establishing a dedicated, standalone individualized medicine clinic.
    • Implementing whole exome sequencing (WES) for clinical applications.
    • Developing processes for the execution and interpretation of WES data.

    Main Results:

    • The institution successfully designed and executed an individualized medicine clinic.
    • Early implementation outcomes and practical lessons learned were documented.
    • The approach demonstrated a pathway to further individualize patient care through clinical genomics.

    Conclusions:

    • Integrating genomic medicine into clinical workflows is feasible through dedicated institutional efforts.
    • Clinical whole exome sequencing can advance individualized medicine and patient care.
    • Lessons learned from this implementation can guide other institutions seeking to adopt genomic medicine.