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Merkel cell carcinoma, version 1.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
|March 12, 2014
Summary
Merkel cell carcinoma, a rare skin cancer, has high recurrence and metastasis rates. Updated NCCN guidelines offer improved diagnosis and management strategies, including new pathology and imaging recommendations.
Area of Science:
- Oncology
- Dermatology
Background:
- Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
- MCC exhibits high rates of local recurrence and distant metastasis, similar to nonmelanoma skin cancers and thick melanoma, respectively.
Purpose of the Study:
- To provide updated clinical evidence and expert consensus for the diagnosis and management of Merkel cell carcinoma.
- To incorporate revisions on PET/CT imaging and pathology principles into clinical guidelines.
Main Methods:
- Review of clinical evidence and expert consensus.
- Inclusion of updated recommendations for diagnostic imaging (PET/CT).
- Addition of a new section detailing principles of pathology for MCC analysis and reporting.
Main Results:
- Revised guidelines for Merkel cell carcinoma diagnosis and management.
- Specific recommendations on the utility and application of PET/CT imaging.
- Guidance on pathology analysis, interpretation, and reporting for MCC.
Conclusions:
- The updated NCCN Guidelines offer a comprehensive framework for managing Merkel cell carcinoma.
- Emphasis on advanced imaging and detailed pathology improves diagnostic accuracy and treatment planning for this aggressive skin cancer.
