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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: May 2, 2026

Merkel Cell Polyomavirus Infection and Detection

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Merkel cell carcinoma, version 1.2014.

Christopher K Bichakjian, Thomas Olencki, Murad Alam

Journal of the National Comprehensive Cancer Network : JNCCN

|March 12, 2014

Summary

This summary is machine-generated.

Merkel cell carcinoma, a rare skin cancer, has high recurrence and metastasis rates. Updated NCCN guidelines offer improved diagnosis and management strategies, including new pathology and imaging recommendations.

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Merkel Cell Polyomavirus Infection and Detection

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Published on: May 18, 2018

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Published on: March 8, 2022

Area of Science:

Oncology
Dermatology

Background:

Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
MCC exhibits high rates of local recurrence and distant metastasis, similar to nonmelanoma skin cancers and thick melanoma, respectively.

Purpose of the Study:

To provide updated clinical evidence and expert consensus for the diagnosis and management of Merkel cell carcinoma.
To incorporate revisions on PET/CT imaging and pathology principles into clinical guidelines.

Main Methods:

Review of clinical evidence and expert consensus.
Inclusion of updated recommendations for diagnostic imaging (PET/CT).
Addition of a new section detailing principles of pathology for MCC analysis and reporting.

Main Results:

Revised guidelines for Merkel cell carcinoma diagnosis and management.
Specific recommendations on the utility and application of PET/CT imaging.
Guidance on pathology analysis, interpretation, and reporting for MCC.

Conclusions:

The updated NCCN Guidelines offer a comprehensive framework for managing Merkel cell carcinoma.
Emphasis on advanced imaging and detailed pathology improves diagnostic accuracy and treatment planning for this aggressive skin cancer.