Related Experiment Video
Updated: May 2, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
Vanishing hypercalciuric kidney stones after treating underlying acromegaly
Eline van der Valk1, Tom Tobe1, Aline Stades2
1Diakonessenhuis Utrecht, Department of Internal Medicine Postbus 80250, 3508 TG, Utrecht The Netherlands.
Unlabelled:
A 53-year-old male presented with recurrent calcium oxalate kidney stones as a first sign of underlying acromegaly, which vanished when his acromegaly was controlled. The exact mechanism behind hypercalciuria and urolithiasis in acromegaly is not yet clear. By discussing this case, a short overview of the pathophysiology of hypercalciuria in acromegaly and practical insights are given.
Learning Points:
Hypercalciuria is a common finding in acromegaly.There are only few reports describing hypercalciuric kidney stones in acromegaly.We assume that in acromegaly there is a primary role of IGF1-mediated, PTH-independent increase in calcitriol synthesis resulting in hypercalciuric kidney stones.
Related Concept Videos
Urinary Tract Calculi III: Medical Management
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Urinary Tract Calculi VI: Surgical Management
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Urinary Tract Calculi I: Introduction
Urinary Tract Calculi V: Nursing Management

