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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

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Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
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Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

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The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
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Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

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Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
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Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

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DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility...
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Related Experiment Video

Updated: May 2, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Hyper IgE syndrome.

Yun Dang1, Jianwen Ren1, Yuanyuan Guo1

  • 1Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Indian Dermatology Online Journal
|March 12, 2014
PubMed
Summary
This summary is machine-generated.

Hyper IgE syndrome (HIES) is a rare condition causing eczema and infections. This case highlights a rare association with epilepsy, increasing awareness for central nervous system involvement in HIES.

Keywords:
Hyper IgE syndromeeczemaepilepsy

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Area of Science:

  • Immunology
  • Neurology
  • Genetics

Background:

  • Hyper IgE syndrome (HIES) is a primary immunodeficiency characterized by eczema, recurrent infections, and extremely high serum IgE levels.
  • Clinical features include characteristic facial features, skeletal abnormalities, and dental issues.
  • Central nervous system (CNS) involvement is infrequently documented in HIES.

Observation:

  • A young patient with HIES presented with seizures, a rare neurological manifestation.
  • This case underscores the importance of considering CNS complications in HIES patients.

Findings:

  • The study details a case of HIES with an unusual comorbidity of epilepsy.
  • This presentation expands the known spectrum of HIES neurological manifestations.

Implications:

  • Increased awareness of potential CNS involvement in HIES is crucial for early diagnosis and management.
  • Further research is needed to understand the mechanisms linking HIES and neurological disorders like epilepsy.
  • This case highlights the need for comprehensive patient evaluation in rare diseases.