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Updated: May 2, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

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Published on: June 14, 2016

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Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity

Ermanno Eleuteri1, Antonino Di Stefano, Davide Vallese

  • 1Divisione di Cardiologia Riabilitativa e Laboratorio di Citoimmunopatologia Apparato Cardio-Respiratorio, Fondazione Salvatore Maugeri , IRCCS, Veruno, NO , Italy .

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|March 13, 2014
PubMed

Insights

In chronic heart failure (CHF), serum levels of procollagen type III (PIPIII) and the BMPs inhibitor CRIM1 are elevated. This suggests a pro-fibrotic imbalance, highlighting potential therapeutic targets for heart failure.

Area of Science:

  • Cardiology
  • Biochemistry
  • Molecular Biology

Background:

  • Chronic heart failure (CHF) involves complex mechanisms including fibrosis.
  • Identifying regulators of fibrosis is crucial for understanding CHF progression.

Purpose of the Study:

  • To quantify serum levels of key fibrosis regulators in patients with CHF.
  • To investigate the relationship between these regulators and disease severity.

Main Methods:

  • Enzyme-linked immunosorbent assays (ELISA) were employed.
  • Serum samples from 66 CHF patients (NYHA classes I-III) and 14 controls were analyzed.
  • Quantified markers included procollagen type I and III (PIPI and PIPIII), collagen I and III, BMPs (1, 2, 3, 7), SDF1α, CXCR4, fibulin family, BMPER, CRIM1, and BAMBI.

Main Results:

  • Elevated serum levels of PIPIII, SDF1α, and CRIM1 were observed in CHF patients compared to controls.
  • CRIM1 levels showed a positive correlation with PIPIII levels.
  • TGFβR2 and CRIM1 were also found to be increased in CHF.

Conclusions:

  • The study identified an increase in PIPIII and CRIM1 in CHF patients.
  • The correlation between PIPIII and CRIM1 suggests an imbalance favoring pro-fibrotic processes.
  • CRIM1, an inhibitor of Bone Morphogenetic Proteins (BMPs), may play a significant role in CHF-associated fibrosis.
Abstract

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