Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

23
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
23
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

1.8K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extension of the Phase 3 Trial of Somatrogon in Children with Growth Hormone Deficiency: 3 Years of Safety and Efficacy.

Hormone research in paediatrics·2026
Same author

Characterization of Pulmonary Dysfunction in Systemic Juvenile Idiopathic Arthritis Using Xenon and Proton MRI.

Pediatric pulmonology·2026
Same author

Kidney pathology findings in pediatric patients with kidney injury and inflammatory bowel disease: a case series.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Tracing the molecular route to progression in miRNA-biogenesis-defective thyroid lesions.

JCI insight·2026
Same author

Recommendations From the Blue Ribbon Panel on Fluoroscopy Safety.

Journal of the American College of Radiology : JACR·2026
Same author

The Extracorporeal Life Support Organization Registry Data Quality and Integrity Program.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026

Related Experiment Video

Updated: May 2, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.1K

Exploring the association Between DICER1 mutations and differentiated thyroid carcinoma.

Leanne de Kock1, Nelly Sabbaghian, Dorothée Bouron-Dal Soglio

  • 1Department of Human Genetics (L.d.K.) and Program in Cancer Genetics, Department of Oncology and Human Genetics (W.D.F.), McGill University, Montreal, Quebec H2W 1S6, Canada; Lady Davis Institute (L.d.K., N.S.), Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada; Department of Pathology (D.B.-D.S., R.C.) and Endocrine Service (C.L.D.), CHU-Sainte Justine and University of Montreal, Montreal, Quebec H3T 1C5, Canada; Department of Pediatric Radiology (R.P.G.), Baylor College of Medicine, Texas Children's Hospital, Houston, Texas 77030; Center for Pediatric Oncology (B.-K.P.), National Cancer Center, Goyang-si, South Korea 410-769; and (J.R.P.) Minneapolis, Minnesota 55454.

The Journal of Clinical Endocrinology and Metabolism
|March 13, 2014
PubMed
Summary

Germline DICER1 mutations predispose individuals to DICER1 syndrome. This study found characteristic somatic DICER1 mutations in differentiated thyroid carcinoma (DTC) in these patients, strengthening the cancer association.

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K
Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

14.7K

Related Experiment Videos

Last Updated: May 2, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.1K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K
Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

14.7K

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Germline DICER1 mutations cause DICER1 syndrome, often associated with thyroid abnormalities like multinodular goiter.
  • Differentiated thyroid carcinoma (DTC) is infrequently observed in DICER1 syndrome pedigrees.
  • Somatic mutations in the DICER1 ribonuclease IIIb domain are found in various tumors.

Observation:

  • This study investigated the presence of characteristic somatic DICER1 mutations in DTCs within germline DICER1 mutation carriers.
  • Three cases of DTC in individuals with suspected DICER1 syndrome were analyzed.

Findings:

  • Somatic DICER1 mutations were identified in 3 DTCs from unrelated germline DICER1 mutation carriers.
  • All patients were diagnosed with pleuropulmonary blastoma (PPB) in infancy, received chemotherapy, and underwent diagnostic radiation.
  • The identified somatic mutations were located in the DICER1 ribonuclease IIIb domain, affecting critical catalytic residues.

Implications:

  • The findings reinforce the link between DTC and DICER1 syndrome.
  • Clinicians should consider the potential association between germline DICER1 mutations, PPB treatment, and subsequent DTC risk.