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The role of antiplatelet therapy in aneurysm coiling

Rudy J Rahme, Samer G Zammar, Tarek Y El Ahmadieh

    Neurological Research
    |March 13, 2014
    PubMed

    Insights

    Antiplatelet therapy is safe and effective for reducing thromboembolic risks during neurointerventional surgery for intracranial aneurysms. Further research is needed to minimize these risks, especially during aneurysm coiling.

    Area of Science:

    • Neurology
    • Neurosurgery
    • Cardiovascular Medicine

    Background:

    • Neurointerventional surgery enables advanced intravascular therapies for neurovascular diseases and stroke.
    • Thromboembolism is a significant complication in neurointerventional procedures, particularly for intracranial aneurysms.
    • Both antiplatelet and anticoagulant therapies are employed to mitigate thromboembolic risks.

    Purpose of the Study:

    • To review the role of antiplatelet therapy in the endovascular management of intracranial aneurysms.
    • To assess the safety and efficacy of antiplatelet agents in reducing thrombotic risk.
    • To evaluate the use of abciximab as a salvage therapy.

    Main Methods:

    • Literature review focusing on antiplatelet therapy in endovascular aneurysm treatment.
    • Analysis of studies on pre-procedural and intra-procedural antiplatelet use.
    • Examination of case reports and studies involving abciximab for thrombus management.

    Main Results:

    • Antiplatelet agents appear safe and effective for reducing thrombotic risk in unruptured aneurysms.
    • Abciximab shows potential safety as a salvage therapy for thrombus formation in ruptured aneurysms with low hemorrhagic complication rates.
    • Further innovation is required to enhance safety and reduce thromboembolic events in aneurysm coiling.

    Conclusions:

    • Antiplatelet therapy is a valuable tool in reducing thromboembolic complications during endovascular aneurysm treatment.
    • Abciximab may serve as a safe option in specific scenarios of thrombus formation.
    • Continued research is essential for optimizing neurointerventional strategies against thromboembolism.

    Keywords:
    Abciximab,Aneurysm,Antiplatelet therapy,Aspirin,Clopidogrel,Coiling,ComplicationThromboembolism,

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