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Updated: May 2, 2026

Nanopore DNA Sequencing for Metagenomic Soil Analysis
Published on: December 14, 2017
Genomics-guided discovery of endophenazines from Kitasatospora sp. HKI 714
Daniel Heine1, Karin Martin, Christian Hertweck
1Leibniz Institute for Natural Product Research and Infection Biology , HKI , Beutenbergstraße 11a, 07745 Jena, Germany , and Friedrich Schiller University , Jena, Germany.
Abstract:
In this study we report on the genomics-guided exploration of the metabolic potential of the newly discovered strain Kitasatospora sp. HKI 714. The bioinformatics analysis of the whole genome sequence revealed the presence of a biosynthetic gene cluster presumably responsible for the biosynthesis of formerly unknown endophenazine derivatives. A 200 L cultivation combined with bioactivity-guided isolation techniques revealed four new natural products belonging to the endophenazines and the 5,10-dihydrophenazines. Detailed descriptions of their biological effects, mainly focused on antimicrobial properties against several mycobacteria, are given.
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