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Refractory sickle cell leg ulcer: is heparan sulphate a new hope?
Shady Hayek1, Saad Dibo1, Joe Baroud1
1Plastic and Reconstructive Surgery, Private Practice, American University of Beirut - Medical Center, Beirut, Lebanon.
Abstract:
Patients with sickle cell disease are known to have recurrent lower extremity ulcers that have a high pain score and are resistant to conventional means of wound therapy. This study reports the successful use of synthetic heparan sulphate (Cacipliq20(®) , OTR3, Paris, France) in the treatment of a sickle cell ulcer that had failed to respond to several other means of treatment. Therapeutic success was assessed by complete wound coverage and vast improvement in pain score. This is the first study to report use of heparan sulphate in sickle cell ulcers.
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