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Updated: May 2, 2026
06:51
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
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Clostridium difficile enteritis: a new role for an old foe
S Killeen1, S T Martin1, J Hyland1
1St. Vincent's University Hospital, Department of Colorectal Surgery, Dublin 4, Ireland.
Summary
Clostridium difficile enteritis, though rare, is increasingly seen. Early diagnosis and treatment are crucial for managing this small bowel infection, with oral metronidazole as a primary therapy.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Small bowel involvement by Clostridium difficile is a growing clinical concern.
- Limited data exists regarding the comprehensive management of C. difficile enteritis.
Purpose of the Study:
- To systematically review and synthesize current literature on C. difficile enteritis.
- To assess the frequency, pathophysiology, risk factors, diagnosis, management, and outcomes of this condition.
Main Methods:
- A systematic literature review was performed.
- Searched databases included PubMed, MEDLINE, and the Cochrane Library.
- Included original articles published from January 1950 to December 2012.
Main Results:
- C. difficile enteritis is uncommon but increasingly diagnosed, with variable presentations.
- Risk factors include emergency surgery, Caucasian ethnicity, and advanced age.
- Oral metronidazole is the first-line treatment; surgery may be necessary for complications.
Conclusions:
- A high index of clinical suspicion is essential for timely diagnosis and treatment.
- Further research, including prospective studies, is needed for asymptomatic cases.
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