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Updated: May 2, 2026
Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
Published on: April 26, 2018
Trends in fluorescence image-guided surgery for gliomas
Jonathan T C Liu1, Daphne Meza, Nader Sanai
1*Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York; ‡Barrow Brain Tumor Research Center, Division of Neurosurgical Oncology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.
Extensive glioma resection improves survival, but current guidance techniques are limited. Intraoperative fluorescence imaging offers a promising solution to enhance surgical precision and improve patient outcomes for glioma treatment.
Area of Science:
- Neurosurgery
- Medical Imaging
- Oncology
Background:
- Extensive surgical resection is linked to improved survival for glioma patients.
- Current neurosurgical guidance lacks sensitivity and specificity at diffuse infiltrative glioma margins, hindering complete resection.
- Achieving radiographically complete resections remains a challenge in glioma surgery.
Purpose of the Study:
- To review fluorescence imaging strategies for neurosurgical guidance in glioma surgery.
- To explore emerging imaging technologies and contrast agents for improved resection.
- To discuss the potential benefits of fluorescence imaging in extending resection margins.
Main Methods:
- Review of wide-field and high-resolution fluorescence imaging strategies.
- Focus on emerging imaging technologies for neurosurgery.
- Evaluation of clinically viable contrast agents for glioma detection.
Main Results:
- Fluorescence imaging presents a potential to improve the extent of glioma resection.
- It may enable surgeons to resect beyond previously defined radiographic margins.
- Emerging technologies and contrast agents are being developed to enhance intraoperative visualization.
Conclusions:
- Intraoperative fluorescence imaging holds significant promise for improving glioma resection extent.
- Further development and validation are needed to translate these technologies into standard neurosurgical care.
- Addressing current limitations can lead to better patient outcomes in glioma treatment.
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