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Related Concept Videos

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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Interference leads to systematic error in atomic absorption (AA) measurements by enhancing or diminishing the analytical signal or the background. These interferences can be grouped into three main categories: spectral interference, chemical interference, and physical interference.
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Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison
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Widespread nanoparticle-assay interference: implications for nanotoxicity testing.

Kimberly J Ong1, Tyson J MacCormack2, Rhett J Clark3

  • 1Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.

Plos One
|March 13, 2014
PubMed
Summary
This summary is machine-generated.

Engineered nanomaterials can interfere with toxicity tests, leading to inaccurate safety assessments. This study highlights the need to account for nanoparticle interference in nanotoxicity evaluations.

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Area of Science:

  • Materials Science
  • Toxicology
  • Analytical Chemistry

Background:

  • Conflicting reports on engineered nanomaterial (ENM) toxicity hinder safety evaluations.
  • ENMs' unique properties can interfere with analytical techniques, potentially causing inaccurate toxicity data.
  • Previous assessments often overlook ENM interference with biochemical assays.

Purpose of the Study:

  • To investigate the interference of ENMs with toxicity assays.
  • To determine if ENM interference can be predicted by their properties or interactions with assay components.
  • To provide guidance for improving the accuracy of nanotoxicity assessments.

Main Methods:

  • Tested four types of ENMs (silicon, cadmium selenide, titanium dioxide, helical rosette nanotubes) across six assays.
  • Evaluated interference from intrinsic ENM properties, ENM-assay component interactions, and combined effects of ENMs and analytes.
  • Simulated realistic assay conditions and conducted a literature survey on nanotoxicity assessment methods.

Main Results:

  • Silicon, cadmium selenide, titanium dioxide, and helical rosette nanotubes interfered with at least one assay, causing significant over- or under-estimations of toxicity.
  • Interference could not be solely predicted by ENM-assay component interactions or current understanding of ENM behavior.
  • A literature survey revealed widespread failure to account for ENM interference in nanotoxicity studies (approx. 95% in 2010, not substantially improved by 2012).

Conclusions:

  • Engineered nanomaterials can significantly interfere with toxicity assessments, leading to unreliable safety data.
  • Current methods are insufficient to predict or control for ENM interference in nanotoxicity testing.
  • Addressing ENM interference is crucial for accurate nanotoxicity evaluation and risk assessment.