Ubiquity: a framework for physiological/mechanism-based pharmacokinetic/pharmacodynamic model development and...

Area of Science:

• Pharmacokinetics and Pharmacodynamics
• Computational Biology
• Scientific Software Development

Background:

• Pharmacokinetic/pharmacodynamic (PK/PD) modeling is crucial for drug development, utilizing differential equation-based models.
• Current software packages present challenges in implementation and data transferability.
• Modelers face complexity in coding and describing physiochemical processes.

Purpose of the Study:

• To develop a novel text-based format for PK/PD modeling.
• To simplify the description of model components based on physiochemical processes.
• To enhance the implementation and transferability of PK/PD models across different software.

Main Methods:

• A new text-based format was created to reduce coding complexity.
• A Perl script was developed to generate model systems for multiple software formats (e.g., ADAPT, MATLAB, Berkeley Madonna).
• Proof-of-concept tools were included for running models in MATLAB, including a stand-alone graphical application.

Main Results:

• The developed format successfully simplifies PK/PD model construction.
• The Perl script enables seamless model analysis across various software platforms.
• Reduced transcription errors and increased model availability were observed.
• MATLAB integration, including a graphical application, was demonstrated.

Conclusions:

• The text-based modeling format significantly improves PK/PD model implementation and transferability.
• This approach enhances workflow efficiency and model accessibility for researchers.
• The developed tools facilitate cross-platform PK/PD model analysis and application.