Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

24
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
24
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.2K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.2K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

46
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
46

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concordance and Prognostic Impact of Tumor-Stroma Ratio and Tumor-Infiltrating Lymphocytes in Preoperative Biopsies and Matched Surgical Specimens in Oral Squamous Cell Carcinoma.

Diagnostics (Basel, Switzerland)·2026
Same author

Is there a beneficial dose of alcohol?

Casopis lekaru ceskych·2026
Same author

Circulating MicroRNAs do not provide a diagnostic benefit over tissue biopsy in patients with brain metastases.

Scientific reports·2025
Same author

Pattern of Mandibular Bone Invasion as a Prognostic Factor.

Diagnostics (Basel, Switzerland)·2025
Same author

Tumor-Stroma Ratio, Infiltrating Lymphocytes, and Their Combined Profiles in Oral Cancer Prognosis.

Oral diseases·2025
Same author

Prognostic impact of immune phenotype in oral squamous cell carcinoma.

Oral oncology·2025

Related Experiment Video

Updated: May 2, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K

Pancreatic pain.

Hana Nechutova1, Petr Dite, Marketa Hermanova

  • 1Second Department of Internal Medicine, St. Anne's University Hospital Brno, Brno, Czech Republic, hankanech@seznam.cz.

Wiener Medizinische Wochenschrift (1946)
|March 13, 2014
PubMed
Summary

Pain management in pancreatic diseases requires understanding specific pain types like nociceptive, neuropathic, and inflammatory pain. Neuromodulatory therapies offer promising treatments for severe, drug-resistant pain syndromes, including chronic pancreatitis.

More Related Videos

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
03:42

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis

Published on: March 15, 2024

1.6K
An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

643

Related Experiment Videos

Last Updated: May 2, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K
Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
03:42

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis

Published on: March 15, 2024

1.6K
An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

643

Area of Science:

  • Pain Medicine
  • Gastroenterology
  • Neurology

Background:

  • Pain is a prevalent symptom across numerous diseases.
  • Recent advancements allow for precise classification and analysis of pain components.
  • Understanding specific pain types is crucial for effective disease-specific treatment, particularly in pancreatopathies.

Purpose of the Study:

  • To summarize pain characteristics in diseases, with a focus on pancreatopathies.
  • To outline therapeutic strategies and analgesic treatment algorithms.
  • To review emerging neuromodulatory therapeutic approaches for severe pain.

Main Methods:

  • Review of current literature on pain classification and treatment.
  • Analysis of pain components (nociceptive, neuropathic, inflammatory) in pancreatic diseases.
  • Exploration of neuromodulatory techniques for drug-resistant pain.

Main Results:

  • Pancreatopathies often involve a combination of nociceptive, neuropathic, and inflammatory pain.
  • Long-term, uncontrolled pain can initiate neuromodulation processes.
  • Neuromodulatory therapies show promise for chronic, severe, and drug-resistant pain, including chronic pancreatitis.

Conclusions:

  • Tailoring analgesic treatment to specific pain types in pancreatopathies is essential.
  • Neuromodulation represents a significant advancement in managing complex pain syndromes.
  • The article provides a comprehensive overview of current and novel therapeutic trends for pancreatic pain.