[Cheilitis granulomatosa and Melkersson-Rosenthal syndrome. Intralymphatic histiocytosis as valuable diagnostic...

Intravascular and/or intralymphatic cell aggregations can occur in malignant tumors as well as in benign reactive conditions, such as chronic inflammatory diseases. This article discusses the valuable histomorphological aspects of intralymphatic histiocytosis (or granuloma) in the differential diagnostics to other entities exemplified by a case report on juvenile cheilitis granulomatosa. In addition other benign entities sometimes presenting with the phenomenon of intravascular histiocytosis (e.g. rheumatoid arthritis, orthopedic metal implants and Rosai-Dorfman disease) are discussed.