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Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
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Hepatitis B and hepatitis C viral infections in patients with chronic lymphocytic leukemia

Gerald Y Minuk, Betty Lerner, Spencer B Gibson

    Canadian Journal of Gastroenterology & Hepatology
    |March 13, 2014
    PubMed

    Insights

    Chronic hepatitis B (HBV) and C (HCV) infections do not appear to influence the development or progression of chronic lymphocytic leukemia (CLL). This study found no significant difference in disease aggressiveness or survival between infected and uninfected CLL patients.

    Area of Science:

    • Hematology
    • Virology
    • Oncology

    Background:

    • The role of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the pathogenesis and progression of chronic lymphocytic leukemia (CLL) remains unclear.
    • Investigating potential links between viral infections and hematological malignancies is crucial for understanding disease development.

    Purpose of the Study:

    • To determine the prevalence of HBV and HCV infections among patients diagnosed with chronic lymphocytic leukemia.
    • To assess whether HBV or HCV infection is associated with more aggressive chronic lymphocytic leukemia disease or altered patient outcomes.

    Main Methods:

    • Sera from 222 chronic lymphocytic leukemia patients and 72 healthy controls were tested for HBV and HCV antibodies using ELISA.
    • Real-time polymerase chain reaction was employed to detect HBV-DNA and HCV-RNA in patient sera and lymphocytes, irrespective of antibody status.
    • Prognostic markers including Rai stage, IgVH mutational status, β2-microglobulin, Zap-70, and CD38 were analyzed.

    Main Results:

    • Prevalence of HBV infection was 6.3% in CLL patients versus 2.8% in controls (P=0.25); HCV markers were found in 1.8% of CLL patients and 1.4% of controls (P=0.81).
    • No significant differences in aggressive disease indicators or survival times were observed between HBV/HCV-infected and uninfected CLL patients.
    • Occult HBV and HCV infections were infrequent in the studied CLL cohort.

    Conclusions:

    • The findings do not support a significant role for HBV or HCV infections in the pathogenesis or clinical course of chronic lymphocytic leukemia.
    • Further research may be warranted to explore other potential co-factors or pathogenetic mechanisms in CLL.
    Abstract

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