Inclusion complexation of phenoxyaliphatic acid derivatives of 3,3'-bis(indolyl)methanes with β-cyclodextrin
A Antony Muthu Prabhu1, G S Suresh Kumar
1Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, 627 012, Tamilnadu, India, antonyphdchem@yahoo.com.
Abstract:
The inclusion complexation behavior of phenoxyaliphatic acid derivatives of 3,3'-bis(indolyl)methane (BIMs 1-5) with β-cyclodextrin (β-CD) were investigated in both solution and solid state by means of UV-Visible, fluorescence spectroscopy, FT-IR and (1)H NMR techniques. The nature of the host-guest inclusion complex between BIMs and β-CD has been elucidated. The experimental results confirmed the existence of 1:1 inclusion complex of BIMs with β-CD. The binding constants describing the extent of formation of the complexes have been determined using Benesi-Hildebrand plots using UV-Vis and fluorescence spectroscopy. BIMs exhibited an affinity for β-CD. The spectral studies suggested the phenyl ring along with alkyl substitutions of BIMs is present inside of β-CD cavity.
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