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Updated: May 2, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers
Harmanpreet Singh1, Rahul Sharma, Munish Joshi
1Department of Pharmaceutics, ISF College of Pharmacy , Moga, Punjab , India.
Abstract:
The aim of the present study is to design a mucoadhesive nano-carrier system which retains at the site of application and maximizes the therapeutic potential of anticancer drug as well as reduces their systemic side effects. In the present study PVA nanofibers of Docetaxel were prepared using electrospinning machine. The resulting nanofibers were characterized through various parameters such as surface morphology, drug loading, in-vitro drug release, tensile strength, mucoadhesiveness, drug permeability, degree of swelling and anticancer activities against selective cell lines to establish their therapeutics potential. On the basis of various evaluation results, we may conclude that the current approach comprising polymeric nanofibers can be successfully used for local delivery of anticancer drug.
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