Meta-analyses between 18 candidate genetic markers and overweight/obesity

Area of Science:

• Genetics
• Obesity Research
• Metabolic Disease

Background:

• Overweight and obesity are significant global health concerns.
• Genetic factors play a crucial role in the development of obesity.
• Identifying specific genetic markers associated with obesity is essential for understanding disease mechanisms.

Purpose of the Study:

• To investigate the associations between 18 candidate genetic markers and the risk of overweight/obesity.
• To conduct a comprehensive meta-analysis of existing genetic association studies.

Main Methods:

• A systematic literature search was performed across multiple databases (PubMed, Embase, SpringerLink, Web of Science, CNKI, Wanfang).
• A meta-analysis was conducted on 72 eligible articles, including data from 56,738 controls and 48,148 overweight/obese individuals.
• Review Manager 5.0 software was used for the meta-analysis.

Main Results:

• The SH2B1 rs7498665 polymorphism showed a significant association with an increased risk of overweight/obesity (OR = 1.21, 95% CI = 1.09-1.34, P = 0.0004).
• The FAIM2 rs7138803 polymorphism was also significantly associated with an increased risk of overweight/obesity (OR = 1.11, 95% CI = 1.01-1.22, P = 0.04).

Conclusions:

• The meta-analysis identified SH2B1 rs7498665 and FAIM2 rs7138803 as significant genetic polymorphisms associated with overweight/obesity.
• These findings underscore the important role of SH2B1 and FAIM2 genes in the pathogenesis of overweight and obesity.