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Does topical voriconazole trigger dysplastic changes on the ocular surface?
Journal of Chemotherapy (Florence, Italy)
|March 14, 2014
Summary
Topical voriconazole may cause ocular surface dysplasia. A case study found mild dysplastic changes in the cornea epithelium of a patient treated for Candida endophthalmitis.
Area of Science:
- Ophthalmology
- Dermatology
- Mycology
Background:
- Systemic voriconazole is known to cause photosensitivity and cutaneous malignancies.
- Candida endophthalmitis is a serious intraocular infection.
Observation:
- A 73-year-old male patient with graft-related Candida endophthalmitis presented with a corneal lesion.
- The patient had been using topical 1% voriconazole for four months.
- The lesion, originating from the nasal limbus, appeared as a whitish gelatinous mass.
Findings:
- In vivo confocal microscopy revealed mild dysplastic changes in the corneal epithelium.
- These findings suggest a potential link between topical voriconazole and neoplastic alterations.
Implications:
- Topical voriconazole may induce ocular surface neoplastic changes, mirroring effects seen with systemic administration.
- Further research is necessary to establish a definitive relationship between topical voriconazole use and ocular surface dysplasia.
- Clinicians should consider monitoring for such changes in patients on long-term topical voriconazole therapy.
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