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Does topical voriconazole trigger dysplastic changes on the ocular surface?

Melis Palamar, Sait Egrilmez, Suzan Guven Yilmaz

    Journal of Chemotherapy (Florence, Italy)
    |March 14, 2014
    PubMed
    Abstract

    Insights

    Topical voriconazole may cause ocular surface dysplasia. A case study found mild dysplastic changes in the cornea epithelium of a patient treated for Candida endophthalmitis.

    Area of Science:

    • Ophthalmology
    • Dermatology
    • Mycology

    Background:

    • Systemic voriconazole is known to cause photosensitivity and cutaneous malignancies.
    • Candida endophthalmitis is a serious intraocular infection.

    Observation:

    • A 73-year-old male patient with graft-related Candida endophthalmitis presented with a corneal lesion.
    • The patient had been using topical 1% voriconazole for four months.
    • The lesion, originating from the nasal limbus, appeared as a whitish gelatinous mass.

    Findings:

    • In vivo confocal microscopy revealed mild dysplastic changes in the corneal epithelium.
    • These findings suggest a potential link between topical voriconazole and neoplastic alterations.

    Implications:

    • Topical voriconazole may induce ocular surface neoplastic changes, mirroring effects seen with systemic administration.
    • Further research is necessary to establish a definitive relationship between topical voriconazole use and ocular surface dysplasia.
    • Clinicians should consider monitoring for such changes in patients on long-term topical voriconazole therapy.
    Keywords:
    Candida,Confocal microscopy,Cornea,Dysplasia,Penetrating keratoplasty,Voriconazole

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