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Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis
1Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
The Journal of Laryngology and Otology
|March 14, 2014
Summary
Chronic rhinosinusitis patients show impaired lung function, particularly obstructive changes. Nasal cytokines like interleukin-5 may contribute to these pulmonary issues.
Area of Science:
- Respiratory Medicine
- Pulmonology
- Immunology
Background:
- A link exists between upper and lower airway diseases.
- Pulmonary function in upper airway disease patients is understudied.
Purpose of the Study:
- To investigate pulmonary function in patients with chronic rhinosinusitis (CRS) and allergic rhinitis.
- To explore correlations between pulmonary function and clinical parameters in CRS.
Main Methods:
- Pulmonary function tests were conducted on 68 CRS without nasal polyps, 135 CRS with nasal polyps, 89 allergic rhinitis patients, and 100 controls.
- Clinical parameters assessed included CRS radiographic severity, serum IgE, nasal cytokine levels, and exhaled nitric oxide.
Main Results:
- Patients with CRS exhibited significantly altered pulmonary function.
- Interleukin-5 levels in nasal secretions correlated significantly with pulmonary function in CRS patients.
Conclusions:
- Obstructive lung function changes are present in patients with CRS.
- Nasal cytokines may play a role in the development of obstructive lung function changes in CRS.
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