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Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay
T Meyer1, G Franke, S K A Polywka
1Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Journal of Clinical Microbiology
|March 14, 2014
Abstract:
A universal PCR assay for bacteria and fungi detected meningitis pathogens in 65% of 20 cerebrospinal fluid (CSF) samples from patients with suspected central nervous system (CNS) infections compared to a 35% detection rate by culture and/or microscopy methods. Thus, the PCR assay can improve the diagnosis rate of infective meningitis when standard methods provide a negative result.
