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Area of Science:

  • Infectious Diseases
  • Urology
  • Public Health

Background:

  • Lymphogranuloma venereum (LGV) is a sexually transmitted infection primarily known for causing inguinal lymphadenopathy and proctocolitis.
  • LGV is caused by specific serovars of Chlamydia trachomatis, including L1, L2, and L3.

Observation:

  • This case report details a patient presenting with a persistent genital ulcer, an atypical manifestation of LGV.
  • The identified LGV serovar was L2b, which is infrequently reported as a cause of genital ulcers in men who have sex with men (MSM) in the United States.

Findings:

  • The persistent genital ulcer was diagnosed as being caused by Lymphogranuloma venereum (LGV) serovar L2b.
  • This presentation highlights an unusual clinical manifestation of LGV in the US MSM population.

Implications:

  • Clinicians should consider LGV in the differential diagnosis for persistent genital ulcers, particularly in at-risk populations.
  • Implementing LGV-specific diagnostic testing is essential for accurate and timely identification of this infection.
  • Raising awareness of atypical LGV presentations can improve early detection and management of sexually transmitted infections.