Insulin sensitivity and albuminuria: the RISC study

Area of Science:

• Cardiovascular Disease Research
• Metabolic Health Studies

Background:

• Albuminuria, even in the normal range, is a known risk factor for cardiovascular diseases.
• Insulin sensitivity is increasingly recognized as a crucial factor in metabolic and cardiovascular health.

Purpose of the Study:

• To investigate the association between insulin sensitivity and albuminuria in healthy, nondiabetic individuals.
• To determine if reduced insulin sensitivity predicts future albuminuria development.

Main Methods:

• 1,415 healthy, nondiabetic participants from the RISC study were analyzed.
• Insulin sensitivity was measured using hyperinsulinemic-euglycemic clamps (M/I value), OGIS, and HOMA-IR.
• Urinary albumin-to-creatinine ratio (UACR) was assessed at baseline and 3-year follow-up.

Main Results:

• No significant cross-sectional association was found between UACR and insulin sensitivity measures.
• Neither OGIS nor HOMA-IR predicted follow-up UACR.
• Baseline M/I value from hyperinsulinemic-euglycemic clamps independently predicted higher follow-up UACR (β = -0.14, P = 0.001).

Conclusions:

• Reduced insulin sensitivity, measured by hyperinsulinemic-euglycemic clamp, is associated with increased albuminuria risk in healthy middle-aged adults.
• This association suggests that impaired insulin sensitivity may contribute to the early stages of albuminuria development.