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Updated: May 2, 2026

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
Published on: June 23, 2018
Impact of residual impurities and contaminants on protein stability
Wei Wang1, Arun Alphonse Ignatius, Santosh V Thakkar
1Pfizer Inc, Chesterfield, Missouri, 63017.
Abstract:
Production of recombinant proteins generates a variety of process-related impurities. The multistep manufacturing processes may introduce many potential contaminants into the final pharmaceutical products. These residual impurities and contaminants can potentially impact the protein stability significantly. In this short review, the authors intend to discuss major sources and types of residual process-related impurities and potential product contaminants, their impact on protein quality/stability, and possible mitigations during product development and manufacturing processes.
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