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Updated: May 2, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
Published on: July 21, 2017
Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo
Yizhou Dong1, Ahmed A Eltoukhy, Christopher A Alabi
1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115, USA.
Abstract:
New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.
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