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Paper spray ionization for ambient inorganic analysis.

Robert B Cody1, A John Dane

  • 1JEOL USA, Inc., 11 Dearborn Rd., Peabody, MA, 01960, USA.

Rapid Communications in Mass Spectrometry : RCM
|March 14, 2014
PubMed
Summary

Paper spray ionization enables ambient inorganic analysis, successfully identifying elements in various samples. While detection limits are higher than some methods, its simplicity offers potential for portable elemental analysis.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Materials Science

Background:

  • Investigating paper spray ionization (PSI) as a novel ambient ionization technique for inorganic analysis.
  • Exploring the feasibility of PSI for elemental detection without complex sample preparation.

Purpose of the Study:

  • To assess the capability of PSI for qualitative and quantitative inorganic analysis.
  • To determine the detection limits and identify potential interferences in PSI.

Main Methods:

  • Aqueous solutions were applied to paper, subjected to high voltage for electrospray, and analyzed using in-source collision-induced dissociation (CID) and high-resolution mass spectrometry.
  • Inductively coupled plasma mass spectrometry (ICP-MS) test mixtures and real-world samples were analyzed.

Main Results:

  • Successfully detected 21 out of 23 elements from an ICP-MS test mixture, primarily as atomic ions or their oxides/hydroxides.
  • Demonstrated excellent linearity for nickel(II) nitrate over a wide concentration range (0.1-1000 ppm) using cobalt(II) nitrate as an internal standard.
  • Applied the method to diverse samples including lead-free solder, pharmaceutical tablets, magnets, and historical pigments.

Conclusions:

  • Paper spray ionization is a viable method for qualitative inorganic analysis and can be adapted for quantitative analysis with internal standards.
  • Initial detection limits range from high parts-per-billion to low parts-per-million, with some limitations due to mass spectral interferences.
  • The simplicity and potential portability of PSI offer unique advantages for specific elemental analysis applications.