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Histologic evaluation of normobaric oxygen therapy safety in an animal model
Esmaeil Idani1, Nastaran Ranjbari2, Farideh Sharifipour3
1Department of Pulmonology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Background:
Oxygen therapy, as a therapeutic modality, can be used for long periods of times. However, it may be accompanied by potential complications and side effects.
Objectives:
To evaluate the side effects of normobaric oxygen therapy in rabbits.
Materials And Methods:
In a double-blind experiment, 28 white New Zealand rabbits were randomized into an oxygen treatment group (n = 14) and a control group (n = 14). The oxygen treatment group received 100% oxygen at a flow rate of 5 L/min for 1 h daily, for 1 month. The animals were euthanized at the end of the study, and following autopsy a histological evaluation was carried out to detect levels of oxygen toxicity in their; lungs, liver, brain, heart, kidney, eyes and spleen.
Results:
Histological evaluation revealed no evidence of toxicity in the examined tissues, compared with the control group.
Conclusions:
Oxygen therapy at a flow rate of 5 L/min for 1 h daily for 1 month had no systemic toxicity and it appears to be safe in rabbits.
