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Updated: May 2, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Interstitial granulomatous dermatitis successfully treated with etanercept
Zavier Shawkat Ahmed1, Sabaa Joad1, Manpreet Singh1
1Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Jamaica, NY, U.S.A.
Patient:
Female, 51 FINAL DIAGNOSIS: Interstitial Granulomatous Dermatitis Symptoms: Joint pain • pruritic rush
Medication:
Etanercept Clinical Procedure: - Specialty: Rheumatology.
Objective:
Rare disease.
Background:
Interstitial granulomatous disease (IGD) is a rare skin condition that presents with erythematous and violaceous plaques, and may be associated with pruritus and pain. The cause remains unknown, but is often associated with autoimmune disease and drug-related adverse effects. It is diagnosed via biopsy, and the treatment remains unclear.
Case Report:
We report a case of biopsy-proven IGD associated with rheumatoid arthritis that was treated successfully with etanercept therapy.
Conclusions:
We emphasize that anti-TNF antibodies may be clinically effective for the treatment of IGD.

