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Established and forthcoming drugs for the treatment of osteoporosis

Willem F Lems1, Piet Geusens

  • 1aVU University Medical Center, Department of Rheumatology, Amsterdam bDepartment of Internal Medicine/Rheumatology, Maastricht University Medical Center and CAPHRI, Maastricht, The Netherlands cBiomedical Research Institute, University Hasselt, Belgium.

Current Opinion in Rheumatology
|March 15, 2014
PubMed
Abstract

Insights

Antiresorptive and osteoanabolic drugs effectively reduce fracture risk in high-risk patients. Emerging therapies like odanacatib and sclerostin inhibitors offer new mechanisms for bone health.

Area of Science:

  • Bone biology and pharmacology
  • Osteoporosis management
  • Fracture prevention strategies

Background:

  • High-risk patients require effective fracture prevention.
  • Antiresorptive and osteoanabolic drugs are key treatments.
  • New therapies are emerging with novel mechanisms.

Purpose of the Study:

  • To review current data on antifracture drugs.
  • To assess efficacy and side-effects of existing therapies.
  • To highlight emerging treatments for osteoporosis.

Main Methods:

  • Review of recent clinical data on osteoporosis medications.
  • Analysis of antifracture efficacy and safety profiles.
  • Identification of novel drug targets and mechanisms.

Main Results:

  • Antiresorptive drugs (bisphosphonates, denosumab) and teriparatide show efficacy in fracture prevention.
  • Rare side-effects exist but are generally outweighed by benefits.
  • New agents like odanacatib and sclerostin inhibitors are promising.

Conclusions:

  • Antiresorptives and teriparatide offer effective fracture prevention with acceptable safety.
  • Odanacatib and sclerostin inhibitors represent promising advancements.
  • Novel mechanisms may decouple bone resorption and formation.

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