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Related Experiment Videos

Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations.

A M Suikkari1, T Sane, M Seppälä

  • 1First Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

The Journal of Clinical Endocrinology and Metabolism
|January 1, 1989
PubMed
Summary

Prolonged exercise significantly elevates serum insulin-like growth factor-binding protein (IGF-BP) in both healthy and type 1 diabetic individuals. These increases correlate inversely with insulin and IGF-I levels in normal men, suggesting IGF-BP

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Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Metabolic Research

Background:

  • Insulin-like growth factor-binding proteins (IGF-BPs) modulate insulin-like growth factor (IGF) bioavailability.
  • The impact of prolonged exercise on IGF-BP levels, particularly in type 1 diabetes, remains incompletely understood.

Purpose of the Study:

  • To investigate the serum IGF-BP response to prolonged exercise in normal and type 1 diabetic men.
  • To examine the relationship between IGF-BP, IGF-I, and insulin levels following endurance exercise.

Main Methods:

  • Two studies involving prolonged exercise: 3-hour cycle ergometer exercise and a 75-km cross-country ski race.
  • Serum concentrations of IGF-BP, IGF-I, and insulin were measured before and after exercise.
  • Correlation analyses were performed to assess relationships between hormonal levels.

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Main Results:

  • Serum IGF-BP concentrations increased significantly (4.2- to 5.4-fold) after prolonged exercise in both normal and type 1 diabetic men.
  • Serum IGF-I levels decreased in normal and diabetic men after the ski race.
  • In normal men, post-exercise IGF-BP levels were inversely correlated with both insulin and IGF-I levels.

Conclusions:

  • Prolonged exercise robustly increases serum IGF-BP concentrations in both healthy individuals and those with type 1 diabetes.
  • The observed increases in IGF-BP during prolonged exercise appear to be inversely related to changes in IGF-I and insulin in normal individuals.
  • These findings suggest a potential role for IGF-BP in regulating IGF-I action during extended physical exertion.