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Evolution of transcatheter aortic valve replacement.

Christos V Bourantas1, Patrick W Serruys

  • 1From the Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, The Netherlands (C.V.B., P.W.S.); and International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom (P.W.S.).

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|March 15, 2014
PubMed
Summary

Transcatheter aortic valve replacement (TAVR) has revolutionized structural cardiology over 20 years. Ongoing advancements address limitations and expand TAVR applications, improving patient outcomes.

Keywords:
aortic valve stenosisprognosis

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Technology

Background:

  • Transcatheter aortic valve replacement (TAVR) emerged approximately 20 years ago, significantly impacting structural interventional cardiology.
  • Early animal studies and initial clinical results demonstrated the feasibility and promise of percutaneous valve implantation.
  • Subsequent industry and scientific efforts over the past 12 years have focused on refining TAVR technology and procedures.

Purpose of the Study:

  • To review the historical evolution of transcatheter aortic valve replacement (TAVR).
  • To present the foundational steps and early evidence in the field of TAVR.
  • To discuss current limitations and future directions for TAVR development.

Main Methods:

  • Review of historical data, including early experiments in animal models.
  • Analysis of evidence from clinical trials and patient registries.
  • Discussion of technological advancements and proposed solutions for TAVR limitations.

Main Results:

  • TAVR has evolved significantly over two decades, transforming treatment for aortic valve disease.
  • Initial promising results have driven substantial innovation to overcome technical challenges.
  • Registries and trials provide evidence supporting TAVR's expanding role and efficacy.

Conclusions:

  • Transcatheter aortic valve replacement represents a major advancement in cardiology.
  • Continued research and development are crucial for addressing TAVR's limitations and enhancing its application.
  • Future perspectives in TAVR aim to improve safety, broaden indications, and optimize patient care.