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Updated: May 2, 2026

Detection of True IgE-expressing Mouse B Lineage Cells
Published on: December 1, 2014
The production and regulation of IgE by the immune system
1Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Abstract:
IgE not only provides protective immunity against helminth parasites but can also mediate the type I hypersensitivity reactions that contribute to the pathogenesis of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. Despite the importance of IgE in immune biology and allergic pathogenesis, the cells and the pathways that produce and regulate IgE are poorly understood. In this Review, we summarize recent advances in our understanding of the production and the regulation of IgE in vivo, as revealed by studies in mice, and we discuss how these findings compare to what is known about human IgE biology.
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