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Inhibition of dopamine beta-hydroxylase by goitrin, a natural antithyroid compound
N Zenker1, L S Hubbard, J Wright
1Department of Medicinal Chemistry/Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore 21201.
Journal of Natural Products
|September 1, 1988
Abstract:
RS-Goitrin can be conveniently prepared by a simplification of the Ettlinger procedure. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase. The administration of goitrin leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine.