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Cerebral microbleeds are associated with deep white matter hyperintensities, but only in hypertensive patients

Zhongbao Gao1, Wei Wang1, Zhenfu Wang1

  • 1Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, People's Republic of China.

Plos One
|March 15, 2014
PubMed

Insights

Hypertension influences the link between cerebral microbleeds (CMBs) and deep white matter hyperintensities (DWMH) in cerebrovascular disease patients. CMBs and DWMH association was significant only in hypertensive individuals.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Cerebral microbleeds (CMBs) and white matter hyperintensities (WMH) are common in small vessel disease and often coexist.
  • Hypertension is a known risk factor for both CMBs and WMH, but its effect on their association is unclear.

Purpose of the Study:

  • To investigate the role of hypertension in the relationship between CMBs and WMH in patients with acute cerebrovascular disease.

Main Methods:

  • 148 patients with acute cerebrovascular disease were recruited.
  • CMBs were assessed using the Brain Observer Microbleed Rating Scale.
  • WMH severity was evaluated for peri-ventricular (PVH) and deep white matter (DWMH) subtypes.

Main Results:

  • CMBs were present in 43.9% of patients and correlated with DWMH and PVH severity.
  • Hypertension was an independent risk factor for CMBs (OR 5.239) and DWMH (OR 2.373).
  • The association between CMBs and DWMH severity was significant only in hypertensive patients (r=0.298, p<0.01), while CMBs associated with PVH independently of hypertension.

Conclusions:

  • Hypertension plays a crucial role in determining the association between CMBs and DWMH.
  • Findings highlight hypertension's impact on small vessel disease manifestations and their interrelation.

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