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[Adverse drug events in hospital: pilot study with trigger tool]
Revista De Saude Publica
|March 15, 2014
Summary
Approximately 16% of hospitalized patients experience adverse drug events, often leading to prolonged hospital stays and temporary harm. Critical appraisal of psychotropic therapy is recommended due to frequent associated events.
Area of Science:
- Pharmacovigilance
- Hospital Pharmacy
- Patient Safety
Context:
- Tertiary care hospitals are complex environments with a high potential for adverse drug events (ADEs).
- Understanding the frequency and characteristics of ADEs is crucial for improving patient outcomes and healthcare quality.
Purpose:
- To estimate the incidence and characterize the adverse drug events in a tertiary care hospital.
- To identify patient demographics, pharmacological classes, and specific drugs associated with ADEs.
Summary:
- A retrospective review of 2,092 patients' medical records identified an ADE incidence of 15.6%.
- ADEs were associated with significantly longer hospital stays (35.2 vs. 10.7 days) and often resulted in temporary harm.
- Cardiovascular, nervous system, and alimentary tract/metabolism drugs were most frequently implicated, with tramadol, dypirone, glibenclamide, and furosemide being common culprits.
Impact:
- The findings highlight the significant burden of ADEs on patients and healthcare resources.
- The study suggests that the trigger-based instrument used can be valuable for monitoring patient care.
- There is a need for critical evaluation of psychotropic therapies due to their association with adverse events like sedation and hypotension.
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