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Aggressive chemotherapy in endodermal sinus tumor.

N Athanikar1, T K Saikia, G Ramkrishnan

  • 1Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India.

Journal of Surgical Oncology
|January 1, 1989
PubMed
Summary
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This study found that intensive chemotherapy containing cisplatin significantly improves survival rates for endodermal sinus tumors. Early detection of recurrence is possible through monitoring serum alpha-fetoprotein (AFP) levels.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Gynecologic Oncology

Background:

  • Endodermal sinus tumors (also known as yolk sac tumors) are rare germ cell tumors.
  • These tumors predominantly affect young patients and are associated with elevated serum alpha-fetoprotein (AFP).

Purpose of the Study:

  • To evaluate the clinical behavior of endodermal sinus tumors.
  • To assess the relationship between serum AFP levels and tumor status.
  • To determine the efficacy of intensive postoperative combination chemotherapy in patients with endodermal sinus tumors.

Main Methods:

  • Retrospective analysis of 28 patients with pure or predominantly endodermal sinus tumors.
  • Serum AFP levels were measured in 17 patients.
  • Seven patients received cisplatin-containing combination chemotherapy post-surgery.

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Main Results:

  • Serum AFP was elevated in all 17 tested patients.
  • Five out of seven patients (71%) treated with adjuvant chemotherapy achieved disease-free survival.
  • Median survival post-treatment was 28 months, with an overall median survival of 34 months.
  • Two patients experienced early recurrence, indicated by a rise in serum AFP prior to clinical symptoms.

Conclusions:

  • Intensive cisplatin-based adjuvant chemotherapy demonstrates significant efficacy in treating endodermal sinus tumors.
  • Monitoring serum AFP is crucial for early detection of recurrence, even before clinical signs appear.