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[Dexamethasone and diclofenac by LC-MS-MS as herbal product adulterants]
Lourdes Garza-Ocañas1, Christian Tadeo Badillo-Castañeda1, Sandra Lucía Montoya-Eguía1
1Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.
Objective:
To confirm the presence of dexamethasone and diclofenac as adulterants of an herbal product.
Materials And Methods:
For identificaction and confirmation of drugs a method of instrumental analysis by liquid chromatography coupled with high pressure tandem mass spectrometry was used.
Results:
The presence of dexamethasone and diclofenac was confirmed in samples of 11 bottles of Reumofan Plus obtained from patients and/or physicians. The methodology used, allowed separation of stereoisomers dexamethasone and betamethasone, the relative abundances of product ions 237.2 and 279.2 m / z spectrally differentiate the compounds.
Conclusions:
The presence of dexamethasone and diclofenac was confirmed in samples of a product marketed as "100% natural" obtained from patients and / or physicians in a period from January to December, 2011.
