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Updated: May 2, 2026

A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Melanoma developed during pregnancy--a case report
Natalia Cammarosano Mestnik1, João Paulo Junqueira Magalhães Afonso2, Milvia Maria Simões e Silva Enokihara3
1Federal University of São Paulo, Paulista School of Medicine, Department of Dermatology, São PauloSP, Brazil, Doctor Dermatologist - Specialising in Dermoscopy at the Department of Dermatology, Paulista School of Medicine - Federal University of São Paulo (EPM-UNIFESP) - São Paulo (SP), Brazil.
Pregnancy can alter pigmented lesions, potentially masking serious conditions like plantar interdigital cutaneous melanoma. Dermatologists must regularly examine pregnant women
Area of Science:
- Dermatology
- Oncology
- Obstetrics
Background:
- Melanoma diagnosis during pregnancy presents unique challenges.
- Pigmented lesions can change during gestation, complicating early detection.
Observation:
- A case of plantar interdigital cutaneous melanoma in a 22-year-old woman is presented.
- The patient noted changes in a pigmented lesion during pregnancy.
Findings:
- The melanoma diagnosis was delayed, leading to an unfavorable outcome.
- Changes in melanocytic lesions during pregnancy should not be dismissed as physiological.
Implications:
- Highlights the critical need for vigilant dermatological surveillance in pregnant women.
- Emphasizes regular examination of melanocytic lesions, regardless of perceived hormonal influence.
- Underscores the potential for delayed diagnosis and adverse outcomes in pregnancy-associated melanoma.
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