Case for diagnosis. Cutaneous involvement associated to multiple myeloma

Area of Science:

• Oncology
• Dermatology
• Hematology

Background:

• Multiple myeloma infrequently presents with cutaneous involvement, occurring in 5-10% of cases.
• Cutaneous metastatic plasmacytomas are exceptionally rare manifestations of this plasma cell dyscrasia.

Observation:

• A 72-year-old male patient with a history of multiple myeloma in remission developed cutaneous tumors.
• Biopsy confirmed the lesions as plasmacytomas.
• The patient received melphalan, prednisolone, and radiotherapy, achieving a good initial response.

Findings:

• Despite treatment, the patient experienced disease progression with new extramedullary plasmacytomas.
• Cutaneous metastatic plasmacytomas were the initial indicators of multiple myeloma progression.

Implications:

• This case highlights the importance of considering cutaneous metastatic plasmacytomas as an early sign of multiple myeloma relapse.
• Dermatologists and oncologists should be vigilant for these skin manifestations in patients with a history of multiple myeloma.
• Prompt diagnosis and management of cutaneous plasmacytomas may be critical for improving patient outcomes in multiple myeloma.