Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

482
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
482
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

6.0K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.0K
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.6K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

749
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
749
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

18
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
18

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of tranexamic acid for acute spontaneous intracerebral haemorrhage: a systematic review and individual patient data meta-analysis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Perihematomal Edema and Functional Outcome After Intracerebral Hemorrhage: A Meta-Analysis of Individual Participant Data.

Stroke·2026
Same author

Ultra-early computed tomography markers of haematoma expansion: Potential trial targets?

European stroke journal·2026
Same author

Global, regional, and national burden of headache disorders, 1990-2021, with forecasts to 2050: A Global Burden of Disease study 2021.

Cell reports. Medicine·2025
Same author

Ultra-early computed tomography markers of haematoma expansion: Potential trial targets?

European stroke journal·2025
Same author

Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.

JAMA neurology·2025

Related Experiment Video

Updated: May 2, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

25.1K

Stroke thrombolysis: save a minute, save a day.

Atte Meretoja1, Mahsa Keshtkaran, Jeffrey L Saver

  • 1From the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia (A.M., M.K., G.A.D., L.C.); Departments of Neurology and Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia (A.M., S.M.D.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (A.M., T.T., M.K.); UCLA Stroke Center, Los Angeles, CA (J.L.S.); John Hunter Hospital and the Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.W.P.); and School of Mathematical and Geospatial Sciences, RMIT University, Melbourne, Australia (M.K., L.C.).

Stroke
|March 15, 2014
PubMed
Summary

Faster stroke thrombolysis treatment significantly increases patient lifetime health benefits. Even small delays reduced by minutes yield substantial gains in disability-free life, especially for younger patients.

Keywords:
strokethrombolytic therapy

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

14.4K
The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

495

Related Experiment Videos

Last Updated: May 2, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

25.1K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

14.4K
The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

495

Area of Science:

  • Neurology
  • Public Health
  • Health Economics

Background:

  • Stroke thrombolysis is a time-sensitive intervention.
  • Limited data exist on the long-term health benefits of minor reductions in treatment delays.

Purpose of the Study:

  • To quantify the patient lifetime benefits associated with faster stroke treatment.
  • To model the impact of reduced onset-to-treatment times on long-term disability and life expectancy.

Main Methods:

  • Utilized observational prospective data from 2258 stroke patients treated with intravenous thrombolysis in Australia and Finland (1998-2011).
  • Modeled the shift in 3-month modified Rankin Scale distributions based on treatment effects from pooled thrombolysis trials.
  • Derived expected lifetime and long-term disability levels corresponding to reduced treatment delays.

Main Results:

  • Each minute of reduced onset-to-treatment time yielded an average of 1.8 days of extra healthy life.
  • Benefits varied by age and stroke severity, with younger patients experiencing greater gains.
  • A 15-minute reduction in treatment delay was equivalent to approximately 1 month of additional disability-free life.

Conclusions:

  • Achievable reductions in stroke thrombolysis delays offer significant and consistent long-term health benefits.
  • Emphasizing the importance of speed in stroke treatment can drive practice changes and improve patient outcomes.