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Stability of etoposide solutions in disposable infusion devices for day hospital cancer practices

Alison Klasen1, Romain Kessari, Lionel Mercier

  • 1Service Interdépartemental de Pharmacologie et d'Analyse du Médicament (SIPAM), Institut Gustave-Roussy, 114, rue Edouard Vaillant, 94805, Villejuif Cedex, France.

Drugs in R&D
|March 15, 2014
PubMed

Insights

Etoposide solutions in disposable infusion devices are stable for pediatric cancer care. This finding supports using these devices for day hospital administration, improving patient and nursing efficiency.

Area of Science:

  • Oncology
  • Pharmaceutical Science
  • Pediatrics

Background:

  • Pediatric cancer patients often receive etoposide and carboplatin chemotherapy in day hospital settings.
  • Disposable infusion devices enhance patient quality of life and nursing efficiency.
  • Stability data for etoposide in these devices is lacking, unlike carboplatin.

Purpose of the Study:

  • To assess the stability of etoposide solutions in disposable infusion devices.
  • To determine the impact of concentration and solvent on etoposide stability.
  • To provide data supporting the use of these devices for pediatric chemotherapy.

Main Methods:

  • Investigated etoposide stability in Intermate® infusion devices.
  • Tested three concentrations (100, 400, 600 mg/L) in sodium chloride 0.9% and dextrose 5% solutions.
  • Analyzed etoposide concentration over 24 hours using high-performance liquid chromatography (HPLC) with UV detection.

Main Results:

  • 100 mg/L etoposide was stable for 24h in NaCl 0.9% and 12h in dextrose 5%.
  • 400 mg/L etoposide was stable for 24h in both NaCl 0.9% and dextrose 5%.
  • 600 mg/L etoposide showed reduced stability (8h in NaCl 0.9%, 6h in dextrose 5%); precipitation was the primary cause of degradation.

Conclusions:

  • Etoposide solutions are stable in Intermate® infusion devices for pediatric day hospital administration.
  • Stability is concentration and solvent dependent, with higher concentrations having shorter stability periods.
  • This study validates the use of these devices for etoposide administration, paving the way for clinical and economic feasibility studies.

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