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Detecting cryptic indirect genetic effects.

Nathan W Bailey1, Jessica L Hoskins

  • 1Centre for Biological Diversity, University of St Andrews, St Andrews, Fife KY16 9TH, United Kingdom. nwb3@st-andrews.ac.uk.

Evolution; International Journal of Organic Evolution
|March 18, 2014
PubMed
Summary
This summary is machine-generated.

Indirect genetic effects (IGEs) influence social traits through cryptic interacting phenotypes. This study identified male startle response as a key mediator for IGEs in Drosophila melanogaster.

Keywords:
Drosophila melanogasterinteracting phenotypeinteraction coefficientphenotypic plasticitysocial evolutionsocial flexibility

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Area of Science:

  • Evolutionary biology
  • Behavioral genetics
  • Animal behavior

Background:

  • Indirect genetic effects (IGEs) influence social traits by altering interacting individuals' phenotypes.
  • Identifying the specific phenotypes mediating IGEs is crucial for predicting evolutionary change but often challenging.
  • Cryptic IGEs, where the transmission pathway is unknown, complicate evolutionary predictions.

Purpose of the Study:

  • To investigate the mechanisms of cryptic indirect genetic effects (IGEs) in Drosophila melanogaster.
  • To identify the interacting phenotype and candidate genes responsible for a strong yet cryptic IGE.
  • To present a methodological framework for detecting cryptic IGEs.

Main Methods:

  • Assaying male leg-tapping behavior in Drosophila melanogaster using inbred lines paired with a common focal male strain.
  • Employing a multiple-regression approach to identify candidate interacting phenotypes.
  • Conducting a genome-wide association analysis to pinpoint candidate genes.

Main Results:

  • A significant, yet cryptic, IGE on male leg-tapping behavior was detected, dependent on the interacting partner's genotype.
  • Male startle response was identified as a candidate interacting phenotype mediating the IGE.
  • The 'slowpoke' gene was identified as the most significant candidate gene potentially underlying the IGE.

Conclusions:

  • A methodological framework was established to detect cryptic IGEs by identifying candidate phenotypes and genes.
  • This approach can reveal the evolutionary dynamics influenced by previously undetected IGEs.
  • Understanding cryptic IGEs is essential for a comprehensive view of social trait evolution.