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Updated: May 2, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids
Jinil Hwang1, Kyungho Park, Juseok Choe
1Department of Chemistry, Chonnam National University , Gwangju 500-757, Republic of Korea.
Abstract:
A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(η(3)-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.
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