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Vitronectin is phosphorylated by a cAMP-dependent protein kinase released by activation of human platelets with
B Korc-Grodzicki1, M Tauber-Finkelstein, D Chain
1Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Biochemical and Biophysical Research Communications
|December 30, 1988
Abstract:
Activation of freshly isolated human platelets with a physiological stimulant (thrombin) causes them to release a cAMP-dependent protein kinase which specifically phosphorylates one plasma protein (Mr 75000). This protein is immunochemically and biochemically identified as vitronectin (also know as S protein), which was previously implicated in blood clotting, complement function and cell adhesion.